Opportunity Information: Apply for RFA CK 16 002
The Centers for Disease Control and Prevention (CDC) offered a cooperative agreement grant opportunity focused on reducing human exposure to blacklegged ticks (Ixodes scapularis) infected with Lyme disease bacteria (Borrelia burgdorferi sensu stricto). Lyme disease is described as the most commonly reported vector-borne disease in the United States, with more than 30,000 confirmed or probable cases reported each year and evidence suggesting the true burden may be roughly ten times higher. Because there is no currently available human vaccine for B. burgdorferi, the opportunity emphasizes prevention through integrated tick and pathogen control strategies that can lower the number of infected, host-seeking ticks on residential properties.
The core purpose of the project is to generate practical, scalable evidence about how well integrated tick vector and rodent reservoir management works when applied to a single property compared to multiple adjacent properties. The idea is that tick exposure risk is shaped not only by tick and host ecology but also by how people actually use their yards and nearby landscapes, and where exposure events are most likely to occur. By explicitly tying control efforts to human landscape use patterns and likely tick encounter locations, the project aims to clarify what scale of intervention is most effective for reducing real-world human risk, not just tick counts in isolation.
The intervention approach highlighted in the description is integrated management, meaning it combines methods that kill host-seeking ticks with methods that target natural rodent reservoirs that maintain and amplify B. burgdorferi in the environment. In practical terms, this kind of integrated strategy is intended to disrupt the cycle that produces infected nymphal ticks, the life stage most often responsible for transmitting Lyme disease to people, while also reducing the density of ticks actively seeking hosts in places where humans spend time.
Administratively, the opportunity is listed as RFA CK 16 002 under CFDA 93.942, categorized under Health, and funded as a cooperative agreement. A cooperative agreement generally indicates substantial involvement by the funding agency in the project beyond what is typical for a standard grant, such as collaboration on study design elements, measurement approaches, or coordination to ensure the work addresses public health priorities. The CDC anticipated making one award, with an award ceiling of $300,000, and the notice makes a strict point that any application requesting more than the ceiling would not be forwarded for peer review or considered for funding.
Eligibility was broad and included many types of public and nonprofit entities as well as educational institutions. Eligible applicants included state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education where applicable); and other organizations. The opportunity was posted with a creation date of November 19, 2015, and an original closing date of February 2, 2016, through CDC’s ERA system.Apply for RFA CK 16 002
- The Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Spatially Scalable Integrated Tick Vector/Rodent Reservoir Management to Reduce Human Risk of Exposure to Ixodes scapularis Ticks Infected with Lyme Disease Spirochetes" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.942.
- This funding opportunity was created on 2015-11-19.
- Applicants must submit their applications by 2016-02-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others.
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Frequently Asked Questions (FAQs)
1. What is the main goal of this CDC cooperative agreement?
The goal is to reduce human exposure to blacklegged ticks (Ixodes scapularis) infected with the Lyme disease bacterium Borrelia burgdorferi sensu stricto, by generating practical and scalable evidence on prevention strategies that can be used in real residential settings.
2. What public health problem is this opportunity trying to address?
The opportunity focuses on Lyme disease, described as the most commonly reported vector-borne disease in the United States. More than 30,000 confirmed or probable cases are reported each year, and the description notes evidence suggesting the true burden may be roughly ten times higher.
3. Why does the opportunity emphasize prevention rather than vaccination?
The description states there is no currently available human vaccine for Borrelia burgdorferi, so prevention is emphasized through strategies that reduce infected ticks and lower the chance of tick encounters in places where people spend time.
4. What type of funding mechanism is this?
This opportunity is funded as a cooperative agreement. That generally means the CDC expects substantial involvement in the project, such as collaboration on study design elements, measurement approaches, or coordination to ensure the work addresses public health priorities.
5. What is the program identification for this funding opportunity?
The opportunity is listed as RFA CK 16 002 under CFDA 93.942, and it is categorized under Health.
6. What kind of intervention strategy is the project expected to study?
The description highlights integrated tick and pathogen control strategies, meaning approaches that combine methods to kill host-seeking ticks with methods that target rodent reservoirs that maintain and amplify Borrelia burgdorferi in the environment.
7. What does "integrated management" mean in the context of this opportunity?
Integrated management, as described, combines two broad elements: (1) approaches that reduce ticks that are actively seeking hosts, and (2) approaches that address natural rodent reservoirs involved in maintaining and amplifying the Lyme disease bacteria. The intention is to disrupt the cycle that produces infected nymphal ticks while also reducing tick presence in areas where people are likely to be exposed.
8. Why are rodents specifically mentioned in the intervention approach?
The opportunity notes that rodent reservoirs play a role in maintaining and amplifying Borrelia burgdorferi in the environment. Targeting reservoirs is presented as one component of an integrated strategy intended to reduce the production of infected nymphal ticks.
9. What is the importance of nymphal ticks in this project description?
The description emphasizes infected nymphal ticks as the life stage most often responsible for transmitting Lyme disease to people. The integrated approach is intended to reduce the number of infected nymphs and lower overall exposure risk.
10. What is the core research question about scale of intervention?
The project is designed to generate evidence on how well integrated tick vector and rodent reservoir management works when applied to a single property compared to multiple adjacent properties, helping clarify what scale of intervention is most effective in real-world settings.
11. Why does the opportunity compare single-property versus multiple-property interventions?
The description suggests that tick exposure risk is shaped not only by tick and host ecology but also by how people use their yards and nearby landscapes. By comparing scales of application, the project aims to determine how intervention coverage influences practical reductions in human risk.
12. How does human behavior and landscape use factor into this opportunity?
The opportunity explicitly ties control efforts to human landscape use patterns and likely tick encounter locations, aiming to understand intervention effectiveness in terms of real-world exposure risk, not only changes in tick counts.
13. Is the focus only on reducing tick numbers?
No. While reducing infected, host-seeking ticks is a key goal, the description emphasizes reducing real-world human risk by linking interventions to where exposure events are most likely to occur based on how people use residential landscapes.
14. Where are interventions expected to be applied?
The description focuses on residential properties and compares outcomes when interventions are applied to a single property versus multiple adjacent properties.
15. How many awards did the CDC anticipate making?
The CDC anticipated making one award.
16. What is the maximum funding amount (award ceiling) for this opportunity?
The award ceiling is $300,000.
17. What happens if an application requests more than the award ceiling?
The notice states that any application requesting more than the ceiling would not be forwarded for peer review or considered for funding.
18. Who is eligible to apply for this CDC opportunity?
Eligibility is broad and includes many public and nonprofit entities and educational institutions, including state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education where applicable); and other organizations.
19. Are tribal entities eligible?
Yes. Federally recognized tribal governments and other tribal organizations are listed as eligible applicants.
20. Are nonprofits required to have 501(c)(3) status?
No. The eligibility list includes nonprofits with or without 501(c)(3) status, with an exclusion note related to institutions of higher education where applicable.
21. Are educational institutions eligible to apply?
Yes. The eligibility list includes public and state-controlled institutions of higher education and private institutions of higher education, as well as independent school districts.
22. Are local governments eligible (cities, counties, townships)?
Yes. State governments, county governments, and city/township governments are included in the eligible applicant types.
23. Are housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are included in the eligibility list.
24. What system was used for submission?
The opportunity was posted with submissions through the CDC ERA system.
25. When was the opportunity created and when did it close?
The creation date is listed as November 19, 2015, and the original closing date is February 2, 2016.
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