Opportunity Information: Apply for RFA MH 23 270
The National Institutes of Health (NIH) funding opportunity RFA-MH-23-270, titled "BRAIN Initiative: Integration and Analysis of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)," is a discretionary grant program that supports the creation of software tools to help researchers visualize, integrate, and analyze data produced under the NIH BRAIN Initiative. The core intent is to strengthen the informatics ecosystem around modern neuroscience by funding projects that turn complex, high-volume brain data into something researchers can explore, interpret, and reuse more effectively. This is an R01 mechanism and explicitly does not allow clinical trials, signaling that NIH is looking for research and development centered on computational methods, analytics, and software infrastructure rather than interventional human studies.
This announcement is a reissue of an earlier solicitation (RFA-MH-22-220) and was updated to comply with the NIH Data Management and Sharing Policy (DMSP). In practical terms, that means applicants should expect strong expectations around how data, code, and other digital research products will be managed, documented, and shared so that the broader community can benefit. While the summary text does not spell out specific sharing requirements, the reference to DMSP compliance is a clear indicator that proposals should incorporate thoughtful plans for reproducibility, accessibility, and long-term usability of outputs such as software, pipelines, and derived datasets.
The opportunity sits within a broader set of BRAIN Initiative informatics programs that are intentionally being built in parallel rather than forced into a single monolithic platform. NIH points to companion efforts focused on (1) developing data standards to describe new and emerging BRAIN-related experiments (RFA-MH-19-146) and (2) creating data infrastructures that can store and serve data generated by multiple experimental groups (RFA-MH-19-145). This FOA complements those programs by emphasizing the analysis and visualization layer: the tools researchers actually use to interrogate those data once they are standardized and hosted. The overall strategy is to build infrastructure that is immediately useful within specific experimental sub-domains (for example, particular modalities, organism types, or recording technologies) rather than trying to solve every informatics need across neuroscience at once.
A key theme is modular growth with future interoperability. NIH frames these efforts as sub-domain specific today, but encourages applicants to design with an eye toward eventual linkages between these ecosystems as the field matures and as scientific understanding and technical standards become more aligned. In other words, a strong application is likely to show how the proposed software will be valuable to a defined community now, while also being engineered in a way that can connect to other tools and data resources later. That can include forward-looking choices like extensible architectures, well-documented APIs, use of community standards where available, and careful attention to metadata and provenance so outputs remain interpretable beyond a single lab or dataset.
Eligibility is broad and includes many types of U.S. governmental entities (state, county, city/township, special districts), independent school districts, and public housing authorities/Indian housing authorities, as well as public and state-controlled institutions of higher education and private institutions of higher education. NIH also allows nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), and small businesses, plus additional categories captured under "others." The FOA also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and certain tribal governments and organizations (including Indian/Native American tribal governments other than federally recognized). Non-U.S. entities (foreign organizations) are also listed among other eligible applicants, indicating an openness to international participation where appropriate under NIH rules.
From an administrative standpoint, the opportunity is categorized under the broad federal activity areas of education, health, income security, and social services, and it is associated with multiple CFDA numbers (93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867), reflecting NIH’s multi-institute structure and the cross-cutting nature of BRAIN-related research support. The opportunity was created on 2023-04-13, and the original closing date listed is 2024-06-07. The provided excerpt does not specify an award ceiling or expected number of awards, so applicants would typically need to consult the full FOA text for budget guidance, project period expectations, review criteria, and any preferred technical scope.
Overall, this grant opportunity is aimed at accelerating neuroscience discovery by funding the practical, usable software layer that makes BRAIN Initiative datasets easier to explore and analyze. It prioritizes community-oriented informatics that serves specific experimental segments right away, while still pushing applicants to build tools that can evolve toward broader interoperability as standards, repositories, and scientific questions converge over time.Apply for RFA MH 23 270
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative: Integration and Analysis of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2023-04-13.
- Applicants must submit their applications by 2024-06-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Education, Health, Income Security and Social Services
Next opportunity: Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)
Previous opportunity: Tomorrow’s Leaders Gender Scholars (TLS)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA MH 23 270
Applicants also applied for:
Applicants who have applied for this opportunity (RFA MH 23 270) also looked into and applied for these:
| Funding Opportunity |
|---|
| BRAIN Initiative Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) Apply for RFA MH 23 331 Funding Number: RFA MH 23 331 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed) Apply for RFA TR 23 010 Funding Number: RFA TR 23 010 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Required) Apply for RFA MH 23 330 Funding Number: RFA MH 23 330 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed) Apply for RFA NS 23 026 Funding Number: RFA NS 23 026 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed) Apply for PAR 23 161 Funding Number: PAR 23 161 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional) Apply for RFA NS 23 025 Funding Number: RFA NS 23 025 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Targeted BRAIN Circuits Planning Projects TargetedBCPP (R34 Clinical Trials Not Allowed) Apply for RFA NS 23 023 Funding Number: RFA NS 23 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $450,000 |
| BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed) Apply for RFA NS 23 024 Funding Number: RFA NS 23 024 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional) Apply for RFA MH 23 295 Funding Number: RFA MH 23 295 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed) Apply for RFA MH 23 290 Funding Number: RFA MH 23 290 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative Partnerships to Advance INterdisciplinary (PAIN) Training in Clinical Pain Research: The HEAL PAIN Cohort Program (T90/R90 Independent Clinical Trial Not Allowed) Apply for RFA NS 24 015 Funding Number: RFA NS 24 015 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed) Apply for PAR 23 199 Funding Number: PAR 23 199 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $220,000 |
| HEAL Initiative: Toward Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required) Apply for RFA AT 24 003 Funding Number: RFA AT 24 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed) Apply for RFA MH 24 280 Funding Number: RFA MH 24 280 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R21 Clinical Trial Not Allowed) Apply for RFA DA 24 064 Funding Number: RFA DA 24 064 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $275,000 |
| HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R01 Clinical Trial Not Allowed) Apply for RFA DA 24 063 Funding Number: RFA DA 24 063 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $400,000 |
| HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional) Apply for RFA NS 24 021 Funding Number: RFA NS 24 021 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Mitigating Health Disparities experienced by People with Disabilities caused by Ableism (R01 Clinical Trial Optional) Apply for RFA HD 24 007 Funding Number: RFA HD 24 007 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $499,999 |
| HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (U24 Clinical Trial Not Allowed) Apply for RFA HD 24 012 Funding Number: RFA HD 24 012 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Justice Community Overdose Innovation Network (JCOIN) - Phase II Coordination and Translation Center (U2C Clinical Trial Optional) Apply for RFA DA 24 069 Funding Number: RFA DA 24 069 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA MH 23 270", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.